The Nagoya Protocol on Access to Genetic Resources and the Fair and Equitable Sharing of Benefits Arising from their Utilization to the Convention on Biological Diversity is an international agreement which aims at sharing the benefits arising from the utilization of genetic resources in a fair and equitable way. It entered into force on 12 October 2014, processes for compliance are being introduced nationally which can complicate access to genetic resources, organisms, for research. Even after almost six years, many countries’ policy, regulatory environment and processes for compliance remain in their infancy. Scientists, institutions and research communities were invited to develop best practice for compliance but to date very few best practices are currently recognised although many are published on the CBD ABS Clearing House. The experiences of CABI in its setting of policy, negotiation of access agreements and introduction of compliant procedures are presented and opened for discussion toward a more coordinated approach to working with the Nagoya Protocol.